The CD163 MicroBead Kit, human has been developed for the enrichment of human cells based on the expression of the CD163 antigen. CD163 is most abundantly expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated
in vitro
in vivo
by anti-inflammatory mediators. Depending on the ligand, crosslinking of CD163 initiates signal transduction leading to the production of proinflammatory cytokines, such as IL-1ß, IL-6, and GM-CSF or the anti-inflammatory cytokine IL-10.

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