Clone:
REA316
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC, MICS, IF, IHC
Alternative names:
SEMA4D, M-sema-G, SEMAJ, coll-4, A8, BB18, GR3

Specifications for CD100 Antibody, anti-human, REAfinity™

Overview

Clone REA316 recognizes the human CD100 antigen, a single-pass type I membrane protein which is also known as semaphorin-4D (SEMA4D). CD100 is strongly expressed in skeletal muscle, and at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung, and pancreas. In the immune system, it is present on peripheral blood lymphocytes, spleen, and thymus, especially interfollicular T cells and B cells in the germinal centers of secondary lymphoid follicles. CD100 is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein and repels axon growth cones in the central nervous system. In the immune system, CD100 plays a critical role by turning off negative signaling by CD72 and significantly enhancing the effects of CD40 on B cell and dendritic cell responses. During skin damage repairs, SEMA4D interacts with plexin B2 on gamma delta T cells to play a role in the healing process.
Additional information: Clone REA316 displays negligible binding to Fc receptors.

Alternative names

SEMA4D, M-sema-G, SEMAJ, coll-4, A8, BB18, GR3

Detailed product information

Technical specifications

CloneREA316
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
,
cynomolgus monkey (
Macaca fascicularis
)
AntigenCD100
Alternative names of antigenSEMA4D, M-sema-G, SEMAJ, coll-4, A8, BB18, GR3
Molecular mass of antigen [kDa]94
Distribution of antigenB cells, T cells, brain, heart, kidney, placenta, small intestine, spleen
Entrez Gene ID10507
RRIDAB_2654321, AB_2654322, AB_2654323, AB_2654324, AB_2654325, AB_2654326, AB_2654327, AB_2654328, AB_2654329, AB_2654330

References for CD100 Antibody, anti-human, REAfinity™

Publications

  1. Herold, C. et al. (1996) CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. J. Immunol. 157(12): 5262-5268
  2. Hall, K. T. et al. (1996) Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc. Natl. Acad. Sci. U.S.A. 93(21): 11780-11785
  3. Basile, J.R. et al. (2005) Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol. Cell. Biol. 25(16): 6889-6898

Related products for
CD100 Antibody, anti-human, REAfinity™

3 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?