Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je

Specifications for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™


Clone REA483 recognizes the human, mouse, and rat C-C motif chemokine 2 (CCL2) antigen, which is also known as monocyte chemotactic protein 1 (MCP-1) or platelet-derived growth factor-inducible protein JE. CCL2 is a member of the C-C chemokine family, and a potent chemotactic factor for monocytes. Human CCL2 is composed of 76 amino acids and is 13 kDa in size. CCL2 is produced either constitutively or after induction by oxidative stress, cytokines, or growth factors. It is produced by many cell types, including endothelial, fibroblasts, epithelial, smooth muscle, mesangial, astrocytic, monocytic, and microglial cells. These cells are important for antiviral immune responses in the peripheral circulation and in tissues. However, monocyte/macrophages are found to be the major source of CCL2. It regulates the migration and infiltration of monocytes, memory T lymphocytes, and natural killer (NK) cells. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis, or atherosclerosis.
Additional information: Clone REA483 displays negligible binding to Fc receptors.

Alternative names

GDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, non-human primate
rhesus monkey (
Macaca mulatta
AntigenCCL2 (MCP-1)
Alternative names of antigenGDCF-2, MCAF, MCP-1, Scya2, Sigje, HC11, SMC-CF, Je
Molecular mass of antigen [kDa]9, 14(separately shown for human and mouse/rat)
Distribution of antigenendothelial cells, epithelial cells, macrophages, monocytes, astrocytes, microglia, fibroblasts, smooth muscle
Entrez Gene ID6347, 20296, 24770
RRIDAB_2651368, AB_2651369, AB_2651370, AB_2651367

Resources for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™


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References for CCL2 (MCP-1) Antibody, anti-human/mouse/rat, REAfinity™


  1. Yoshimura, T. and Leonard, E. J. (1991) Human monocyte chemoattractant protein-1 (MCP-1). Adv. Exp. Med. Biol. 305: 47-56
  2. Deshmane, S. L. et al. (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J. Interferon Cytokine Res. 29(6): 313-326
  3. Kawahara, R. S. et al. (1989) Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4. J. Biol. Chem. 264(2): 679-682

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