Clone:
REA597
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
C-C motif chemokine 19, MIP-3-beta, ELC, MIP-3-β

Specifications for CCL19 (MIP-3β) Antibody, anti-human, REAfinity™

Overview

Clone REA597 recognizes the human CCL19 antigen, which is also known as MIP-3β or ELC (EBI1-ligand chemokine). In general, cytokines are secreted proteins involved in immunoregulatory and inflammatory processes. CCL19 induces its effects on its target cells by binding to the chemokine receptor CCR7. The expression of CCL19 is strongly regulated by the anti-inflammatory cytokine IL-10 and is restricted to lymph nodes, thymus, appendix, and spleen.
Additional information: Clone REA597 displays negligible binding to Fc receptors.

Alternative names

C-C motif chemokine 19, MIP-3-beta, ELC, MIP-3-β

Detailed product information

Technical specifications

CloneREA597
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCCL19 (MIP-3β)
Alternative names of antigenC-C motif chemokine 19, MIP-3-beta, ELC, MIP-3-β
Molecular mass of antigen [kDa]9
Distribution of antigenlymphocytes, thymocytes, lymph node, spleen
Entrez Gene ID6363
RRIDAB_2651358, AB_2651359, AB_2651360, AB_2651361, AB_2651362, AB_2651357

References for CCL19 (MIP-3β) Antibody, anti-human, REAfinity™

Publications

  1. Rossi, D. L. et al. (1997) Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta. J. Immunol. 158(3): 1033-1036
  2. Robbiani, D. F. et al. (2000) The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103(5): 757-768
  3. Yoshida, R. et al. (1997) Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7. J. Biol. Chem. 272(21): 13803-13809

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