CD87 antibodies, human

CD87 antibodies, human

Clone: REA892 | Dilution: 1:50
Clone REA892 recognizes the human CD87 antigen, a 36–38 kDa GPI-anchored cell-surface receptor. CD87, also known as uPAR, binds uPA and thus facilitating the catalytic C domain of the uPA to come in close proximity of membrane bound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in-turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. The expression of membrane-bound CD87 is found on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. Multiple known regulatory functions of CD87 include cell migration, leukocyte adhesion, chemotaxis, signal transduction, and tissue remodeling.
Additional information: Clone REA892 displays negligible binding to Fc receptors.

Alternative names

PLAUR, U-PAR, URKR, uPAR, MO3

Technical specifications

  • Antigen: CD87
  • Clone: REA892
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PLAUR, U-PAR, URKR, uPAR, MO3
  • Entrez Gene ID: 5329
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: granulocytes, monocytes, macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. May, A. E. et al. (1998)
      Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins
      in vivo
      .
      J. Exp. Med. 188: 1029-1037
    2. Tarui, T. et al. (2001) Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J. Biol. Chem. 276: 3983-3990
    3. Ge, Y. et al. (2003) Urokinase plasminogen activator receptor (CD87): something old, something new. Lab. Hematol. 9(2): 67-71
Product options: 10
130-114-891

CD87-FITC, human

for 30
tests
(1)
CHF  100.00
130-114-849

CD87-FITC, human

for 100
tests
(1)
CHF  245.00
130-114-892

CD87-PE, human

for 30
tests
(1)
CHF  120.00
130-114-850

CD87-PE, human

for 100
tests
(1)
CHF  290.00
130-114-893

CD87-APC, human

for 30
tests
(1)
CHF  120.00
130-114-851

CD87-APC, human

for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  100.00
for 100
tests
(1)
CHF  245.00

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