CD321 (JAM1) antibodies, human

CD321 (JAM1) antibodies, human

Clone: REA605 | Dilution: 1:11
Clone REA605 recognizes the human CD321 antigen, a cell-surface adhesion molecule, also known as JAM1 or JAMA. CD321 is a type I transmembrane glycoprotein belonging to the immunoglobin superfamily. It has two extracellular Ig-like domains, a transmembrane region and a short cytosolic tail.
CD321 is expressed on a variety of cell types: erythrocytes, leukocytes, platelets, as well as endothelial and epithelial cells. CD321 has different functions. It is a regulator of tight junction assembly in epithelia and acts as a receptor for reovirus. Furthermore CD321 binds integrin LFA1 and is involved in leukocyte transmigration. In addition, CD321 is a platelet receptor.
Additional information: Clone REA605 displays negligible binding to Fc receptors.

Alternative names

JAM-1, JAM-A, PAM-1, F11 R

Technical specifications

  • Antigen: CD321 (JAM1)
  • Clone: REA605
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: JAM-1, JAM-A, PAM-1, F11 R
  • Entrez Gene ID: 50848
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: red blood cells, leukocytes, platelets, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Ozaki, H. et al. (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163(2): 553-557
    2. Sobocka, M. B. et al. (2000) Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95(8): 2600-2609
    3. Fraemohs, L. et al. (2004) The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain. J. Immunol. 173(10): 6259-6264
Product options: 16
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CHF  315.00
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tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  100.00
for 100
tests
(1)
CHF  245.00

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