CD309 (VEGFR-2) antibodies, human

CD309 (VEGFR-2) antibodies, human

Clone: ES8-20E6 | Dilution: 1:11
The CD309 antibody recognizes the CD309 antigen, a transmembrane tyrosine kinase, and is also known as vascular endothelial growth factor receptor-2 (VEGFR-2) or kinase insert domain–containing receptor (KDR). CD309 is a high-affinity receptor for VEGF and plays a role in hematopoiesis. It is also involved in angiogenesis, both during embryogenesis and in the context of homeostatic or pathological events, e.g., vascularization of tumors. It has been identified on a subset of hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), as well as on their common progenitor, the hemangioblast. CD309 expression is also found on mature endothelial cells (ECs).

Alternative names

KDR, Flk1, VEGFR, VEGFR2

Technical specifications

  • Antigen: CD309 (VEGFR-2)
  • Clone: ES8-20E6
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: KDR, Flk1, VEGFR, VEGFR2
  • Entrez Gene ID: 3791
  • Molecular mass of antigen [kDa]: 149
  • Distribution of antigen: endothelial cells, megakaryocytes, pancreas, platelets, ES and iPS cells, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Auerbach, R. et al. (1996) Hematopoietic stem cells in the mouse embryonic yolk sac. Stem Cells 14: 269-280
    2. Eichmann, A. et al. (1997) Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic Proc. Natl. Acad. Sci. U.S.A. 94: 5141-5146
    3. Shalaby, F. et al. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376: 62-66
    4. Flamme, I. et al. (1995) Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (flk-1) are expressed during vasculogenesis and vascular differentiation in the quail embryo. Dev. Biol. 169: 699-712
Product options: 1
100 µg in 1 mL
CHF  105.00