CD307b (FcRL2) antibodies, human

Clone: REA474 | Dilution: 1:11
Clone REA474 recognizes the human CD307b antigen, a single-pass type I membrane protein, which is also known as Fc receptor-like protein 2 (FcRL2) or immunoglobulin receptor translocation-associated protein 4 (IRTA4). CD307b is a protein with immunomodulatory potential that is preferentially expressed by memory B cells in humans. It has two consensus ITIMs in addition to a putative ITAM sequence in its cytoplasmic domain. Coligation of CD307b with the B cell receptor (BCR) leads to tyrosine phosphorylation of its ITIM motifs and subsequent Src homology region 2 domain-containing phosphatase-1 recruitment to facilitate inhibition of BCR signaling. Mutational analysis indicates that the tyrosine residues in both inhibitory motifs of CD307b are required for complete inhibition of BCR signaling, whereas tyrosines in the putative activation motif are dispensable for signal modulation. These findings suggest a negative immunomodulatory function for CD307b in the regulation of memory B cells.
Additional information: Clone REA474 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD307b (FcRL2)
  • Clone: REA474
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCRL2, FcRH2, IFGP4, IRTA4, SPAP1, SPAP1A, SPAP1B, SPAP1C
  • Entrez Gene ID: 79368
  • Molecular mass of antigen [kDa]: 53
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin, PE
  • Selected references

    1. Davis, R. S. et al. (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. U.S.A. 98(17): 9772-9777
    2. Jackson, T. A. et al. (2010) FcR-like 2 inhibition of B cell receptor-mediated activation of B cells. J. Immunol. 185(12): 7405-7412
    3. Shabani, M. et al. (2014) Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling. Immunology 143(3): 341-353
Product options: 4
for 30
CHF  131.00
for 100
CHF  310.00
for 30
CHF  110.00
for 100
CHF  263.00

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