CD3 antibodies, mouse

CD3 antibodies, mouse

Clone: REA641 | Dilution: 1:10
Clone REA641 recognizes the mouse CD3 complex, which is expressed on all mature T lymphocytes, NKT cells, and during the development of thymocytes. CD3, also known as T3, belongs to the Ig superfamily. It consists of CD3ε, δ, γ, and ζ chains and forms a TCR complex by associating with TCR α/β or γ/δ chains. The TCR does not possess intracellular signaling domains, uncoupling Ag recognition from T cell signaling. The TCR is instead non-covalently associated with a multisubunit signaling apparatus, consisting of the CD3εγ and CD3εδ heterodimers and the CD3ζζ homodimer, which collectively form the TCR-CD3 complex. CD3 is involved in T cell activation, signal transduction, and antigen recognition by binding the peptide/MHC antigen complex.
Additional information: Clone REA641 displays negligible binding to Fc receptors.

Alternative names

T cell antigen receptor complex, T3, AI504783, CD3epsilon, T3E, Ctg-3, Ctg3, T3g

Technical specifications

  • Antigen: CD3
  • Clone: REA641
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: T cell antigen receptor complex, T3, AI504783, CD3epsilon, T3E, Ctg-3, Ctg3, T3g
  • Entrez Gene ID: 12501, 12502
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: NKT cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin
  • Selected references

    1. Gold, D. P. et al. (1987) Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc. Natl. Acad. Sci. U.S.A. 84(21): 7649-7653
    2. Miescher, G. C. et al. (1989) Production and characterization of a rat monoclonal antibody against the murine CD3 molecular complex. Immunol. Lett. 23(2): 113-118
    3. Exley, M. et al. (1991) Structure, assembly and intracellular transport of the T cell receptor for antigen. Semin. Immunol. 3(5): 283-297
    4. Birnbaum, M. E. et al. (2014) Molecular architecture of the αβ T cell receptor-CD3 complex. Proc. Natl. Acad. Sci. U.S.A. 111(49): 17576-17581
Product options: 4
130-109-880

CD3-APC, mouse

9 µg in 300 µL (1)
CHF  65.00
130-109-838

CD3-APC, mouse

30 µg in 1 mL (1)
CHF  65.00
9 µg in 300 µL (1)
CHF  28.00
30 µg in 1 mL (1)
CHF  40.00