CD299 (L-SIGN) antibodies, human

CD299 (L-SIGN) antibodies, human

Clone: REA587 | Dilution: 1:11
Clone REA587 recognizes the human CD299 (L-SIGN) antigen, a type II integral membrane protein, also known as C-type lectin domain family 4 member M (CLEC4M) or liver/lymph node-specific ICAM-3-grabbing non-integrin. CD299 is expressed by sinusoidal endothelial cells in lymph nodes and is found in placental endothelium but not in macrophages. It is also expressed in type II alveolar cells and lung endothelial cells. CD299 has a high affinity for both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.
Additional information: Clone REA587 displays negligible binding to Fc receptors.

Alternative names

L-SIGN, DC-SIGN-related protein, CLEC4M

Technical specifications

  • Antigen: CD299 (L-SIGN)
  • Clone: REA587
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: L-SIGN, DC-SIGN-related protein, CLEC4M
  • Entrez Gene ID: 10332
  • Molecular mass of antigen [kDa]: 45
  • Distribution of antigen: endothelial cells, placenta
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Pöhlmann, S. et al. (2001) DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans. Proc. Natl. Acad. Sci. U.S.A. 98(5): 2670-2675
    2. Bashirova, A. A. et al. (2001) A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J. Exp. Med. 193(6): 671-678
    3. Jeffers, S. A. et al. (2004) CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. U.S.A. 101(44): 15748-15753
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CHF  290.00
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CHF  130.00
for 100
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CHF  315.00
for 30
tests
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CHF  130.00
for 100
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CHF  315.00
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CHF  100.00
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CHF  245.00

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