CD268 antibodies, mouse

CD268 antibodies, mouse

Clone: REA1217 | Dilution: 1:50
Clone REA1217 recognizes the CD268 protein, also known as B cell activation factor receptor (BAFF-R), which is a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases.
Additional information: Clone REA1217 displays negligible binding to Fc receptors.

Alternative names

BAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3

Technical specifications

  • Antigen: CD268
  • Clone: REA1217
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: BAFF-R, BLyS receptor 3, TNFRSF13c, BAFFR, Bcmd, BR3
  • Entrez Gene ID: 72049
  • Molecular mass of antigen [kDa]: 19
  • Distribution of antigen: B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, PE-Vio770
  • Selected references

    1. Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293(5537): 2108-2111
    2. Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36(7): 1837-1846
Product options: 4
130-123-433

CD268-PE, mouse

30 µg in 200 µL (1)
CHF  100.00
130-123-434

CD268-APC, mouse

30 µg in 200 µL (1)
CHF  100.00
30 µg in 200 µL (1)
CHF  110.00
30 µg in 200 µL (1)
CHF  110.00