CD253 antibodies, human

CD253 antibodies, human

Clone: REA1113 | Dilution: 1:50
Clone REA1113 recognizes the human CD253 cytokine, a type II transmembrane protein also known as TNF-related apoptosis inducing ligand (TRAIL) or tumor necrosis factor ligand superfamily member 10 (TNFSF10), which induces the process of cell death. CD253 is predominantly found in spleen, lung, and prostate. It binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). CD253 can be expressed on transformed and virus infected cells. It can also be expressed on activated lymphocytes.
Additional information: Clone REA1113 displays negligible binding to Fc receptors.

Alternative names

TNFSF10, APO2L, Apo-2L, TL2, TRAIL

Technical specifications

  • Antigen: CD253
  • Clone: REA1113
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFSF10, APO2L, Apo-2L, TL2, TRAIL
  • Entrez Gene ID: 8743
  • Molecular mass of antigen [kDa]: 33
  • Distribution of antigen: B cells, dendritic cells, NK cells, T cells, monocytes, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, PE-Vio615, VioBright 515
  • Selected references

    1. Wiley, S. R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3(6): 673-682
    2. Pitti, R. M. et al. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271(22): 12687-12690
    3. Almasan, A. et al. (2003) Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev. 14(3-4): 337-348
Product options: 6
130-119-384

CD253-PE, human

for 30
tests
(1)
CHF  120.00
130-119-284

CD253-PE, human

for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  165.00
for 100
tests
(1)
CHF  395.00

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