CD202b pY1102 antibodies, human

CD202b pY1102 antibodies, human

Clone: REA583 | Dilution: 1:11
Clone REA583 recognizes the Y1102-phosphorylated form of CD202b, which is 145 kDa type I transmembrane tyrosine kinase receptor. CD202b is composed of an amino-terminal ligand binding domain with immunoglobulin domains, epithelial growth factor repeats, and fibronectin-like 3 repeats, a single transmembrane domain, and an intracellular tyrosine kinase domain. Expression of CD202b is found on endothelial cells and a subpopulation of monocytes. Angiopoietins are the natural ligands of CD202b. Activation of CD202b dependent signaling pathways are involved in survival and apoptosis of endothelial cells, in controlling vascular permeability, and regulation of the capillary sprouting that occurs during normal angiogenesis.
Additional information: Clone REA583 displays negligible binding to Fc receptors.

Alternative names

TIE2, TIE-2, p140 TEK

Technical specifications

  • Antigen: CD202b pY1102
  • Clone: REA583
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: TIE2, TIE-2, p140 TEK
  • Entrez Gene ID: 7010
  • Molecular mass of antigen [kDa]: 124
  • Distribution of antigen: endothelial cells, hematopoietic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Schnurch, H. et al. (1993) Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage. Development 119: 957-968
    2. Sato, T. N. et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc. Natl. Acad. Sci. U.S.A. 90: 9355-9358
    3. Murdoch, C. et al. (2007) Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J. Immunol. 178: 7405-7411
Product options: 2
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00

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