Anti-Phosphotyrosine antibodies, human and mouse

Anti-Phosphotyrosine antibodies, human and mouse

Clone: REA374 | Dilution: 1:11
Clone REA374 recognizes phosphorylated tyrosine residues (p-Tyr) on proteins. Phosphorylation of proteins is an important regulatory mechanism that occurs in numerous intracellular signaling cascades. Within a protein, phosphorylation usually occurs on serine, threonine, tyrosine, and histidine residues. Phosphorylation on serine is the most common, followed by threonine. Tyrosine phosphorylation is relatively rare but is at the origin of protein phosphorylation signaling pathways in most of the eukaryotes.
Additional information: Clone REA374 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: Phosphotyrosine
  • Clone: REA374
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Cross-reactivity: dog, rat, chicken, frog
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Vio515
  • Selected references

    1. Takagi, S. et al. (1991) Intracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells. J. Exp. Med. 174(2): 381-388
    2. Lund-Johansen, F. et al. (2000) Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions. Cytometry 39(4): 250-259
    3. Zentilin, L. et al. (2010) Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J. 24(5): 1467-1478
Product options: 8
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  305.00

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