Anti-Ly-49H antibodies, mouse

Anti-Ly-49H antibodies, mouse

Clone: REA241 | Dilution: 1:10
Clone REA241 recognizes mouse lymphocyte antigen 49H (Ly-49H) which is also known as killer cell lectin-like receptor 8, Klra8, or Cmv-1. REA241 does not crossreact with related molecules like Ly-49A, C, D, or G2. Ly-49H is a member of the C-type lectin Ly-49 multigene family and is expressed by C57BL/6 and NWNA but not by BALB/c and DBA/2 mouse NK cells. It recognizes a ligand from mouse cytomegalovirus (MCMV), and engagement of Ly-49H can lead to killing of MCMV-infected cells. In addition to NK cell cytotoxicity, Ly-49H has a crucial role in supporting NK cell proliferation to prevent immunopathology caused by the adaptive immune system.
Additional information: Clone REA241 displays negligible binding to Fc receptors.

Alternative names

Klra8, Cmv-1, Cmv1

Technical specifications

  • Antigen: Ly-49H
  • Clone: REA241
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klra8, Cmv-1, Cmv1
  • Entrez Gene ID: 16639
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Smith, K. M. et al. (1989) Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161: 7-10
    2. Seung-Hwan, L. et al. (2003) Transgenic expression of the activating natural killer receptor Ly49H confers resistance to cytomegalovirus in genetically susceptible mice. J. Exp. Med. 197(4): 515-526
    3. Seung-Hwan, L. et al. (2009) Activating receptors promote NK cell expansion for maintenance, IL10 production, and CD8 T cell regulation during viral infection. J. Exp. Med. 206: 2235-2251
Product options: 14
9 µg in 300 µL (1)
CHF  33.00
30 µg in 1 mL (1)
CHF  45.00
9 µg in 300 µL (1)
CHF  42.00
30 µg in 1 mL (1)
CHF  85.00
9 µg in 300 µL (1)
CHF  65.00
30 µg in 1 mL (1)
CHF  85.00
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00
9 µg in 300 µL (1)
CHF  28.00
30 µg in 1 mL (1)
CHF  45.00

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