Anti-DCIR antibodies, human

Anti-DCIR antibodies, human

Clone: REA329 | Dilution: 1:11
Clone REA329 recognizes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34
+
progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation.
Additional information: Clone REA329 displays negligible binding to Fc receptors.

Alternative names

CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR

Technical specifications

  • Antigen: DCIR
  • Clone: REA329
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR
  • Entrez Gene ID: 50856
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: dendritic cells, monocytes, macrophages, B cells, lymphocytes, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Bates, E. E. et al. (1999) APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J. Immunol. 163(4): 1973-1983
    2. Richard, M. et al. (2002) The expression pattern of the ITIM-bearing lectin CLECSF6 in neutrophils suggests a key role in the control of inflammation. J. Leukoc. Biol. 71(5): 871-880
    3. Bloen, K. et al. (2013) Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain. PLoS One 8(6): e66266
Product options: 12
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CHF  290.00
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CHF  290.00
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CHF  130.00
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CHF  315.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  100.00
for 100
tests
(1)
CHF  245.00

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