Anti-CX3CR1 antibodies, human

Anti-CX3CR1 antibodies, human

Clone: 2A9-1 | Dilution: 1:11
CX3CR1 is a transmembrane chemokine receptor with a molecular mass of 40 kDa. It binds the chemokine CX3CL1, also known as fractalkine or neurotactin. Binding of CX3CR1 to the membrane‑bound form of fractalkine promotes cell-cell adhesion, wheras the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia.¹ CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs.² Failure in the fractalkine/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis.

Alternative names

CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28

Technical specifications

  • Antigen: CX3CR1
  • Clone: 2A9-1
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28
  • Entrez Gene ID: 1524
  • Molecular mass of antigen [kDa]: 40
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Imai, T. et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530
    2. Niess, J. H. et al. (2005)
      CX
      3
      CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance.
      Science 307: 254-258
Product options: 7
for 30
tests
(1)
CHF  120.00
for 100
tests
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CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 100
tests
(1)
CHF  245.00

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