ODN 2088

ODN 2088

TLR7/8/9 antagonists consist of short single-stranded oligodeoxynucleotides. They can inhibit CpG ODN-mediated activation of TLR9 and/or activation of TLR7/8.
ODN 2088 is a TLR7/8/9 antagonist. The sequence can form G-Tetrad structures.

Background information

TLR7, TLR8 and TLR9 are prominent members of the Toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns recognizing nucleic acids
3
. Activation of these TLRs can be inhibited by short single-stranded synthetical oligodeoxyribonucleotides (ODNs)
4,6
. Several classes of and motifs for inhibitory ODN have been identified
1,6,7
.

Applications

TLR7/8/9 Antagonists can be used to inhibit TLR7/8/9 mediated cellular responses, such as activation of immune cells, human PBMCs, murine splenocytes or isolated immune cells (e.g., B cells and pDCs).
TLR7/8/9 Antagonists can be used to inhibit signaling in TLR7/8/9-
expressing recombinant cell lines.
ODN 2088 is a widely used inhibitory ODN inhibiting TLR7, TLR8 and TLR9
1,2,4-7
. ODN 2088 forms tertiary structures (G tetrads).
  • Selected references

    1. Krieg A.M. et al. (1998) Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs Proc. Natl. Acad. Sci. U.S.A. 95: 12631-12636
Product options: 2
130-105-815

ODN 2088

200 µg
CHF  211.00
130-105-816

ODN 2088

1 mg
CHF  729.00