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As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is committed to providing our customers around the world with the highest quality products. In addition to direct selling in more than 20 countries in North America, Europe and Asia/Pacific, Miltenyi Biotec also provides support for our customers through an extensive distributor network covering dozens of additional countries.
Toll-like receptors (TLR) 7, 8, and 9 are involved in the early innate immune response as they help to recognize bacterial and viral pathogens. While TLR7/8 bind to single-stranded (ss) RNA, TLR9 is activated via unmethylated CpG-containing motifs of bacterial and viral DNA. The receptors are located in the endosomal compartment and signal via recruitment of MYD88 (myeloid differentiation primary response 88). The signaling cascade results in the activation of transcription factors NF-κB, AP-1, and/or IRF-7, which induces the expression of pro-inflammatory cytokines and type I IFNs.
While binding of agonists activates receptors, antagonist block the receptors and inhibit the interaction of agonist and receptor, which causes a weakened biological response to agonists. Our TLR7/8/9 antagonist ODN 2088 is a short single-stranded oligodeoxynucleotide (ODN) that can inhibit CpG ODN–mediated activation of TLR9 and activation of TLR7/8. In addition to our TLR antagonist, we offer controls with distinct inhibitory capacities.
We offer the TLR antagonist ODN 2088 and different sequence controls.
Table 1: Overview of available TLR7/8/9 antagonists and respective controls.
*Phosphorothioate backbone
| Product | Sequence | Inhibits | ||
|---|---|---|---|---|
| TLR7 | TLR8 | TLR9 | ||
| ODN 2088 | dT*dC*dC*dT*dG*dG*dC*dG*dG*dG*dG*dA*dA*dG*dT | Yes | Yes | Yes |
| ODN 2088 Control (ODN 2087) | dT*dC*dC*dT*dG*dA*dG*dC*dT*dT*dG*dA* dA*dG*dT | Yes | Yes | No |
| ODN 2088 Control (ODN 20958) | dT*dC*dC*dT*dA*dA*dC*dA*dA*dA*dA*dA*dA*dA*dT | Yes | No | No |
| ODN 2088 Control (ODN 20959) | dT*dA*dA*dT*dG*dG*dC*dG*dG*dG*dG*dA*dA*dG*dT | Yes | Yes | No |
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