Find the products and resources you are looking for!
Get in touch!
Our local employees are always happy to answer your questions. Highly trained and experienced teams in your country can provide quick, helpful, and comprehensive support.
Miltenyi Biotec distribution:
As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is committed to providing our customers around the world with the highest quality products. In addition to direct selling in more than 20 countries in North America, Europe and Asia/Pacific, Miltenyi Biotec also provides support for our customers through an extensive distributor network covering dozens of additional countries.
As a global market leader with numerous subsidiaries and distributors, Miltenyi Biotec is committed to providing our customers around the world with the highest quality products. In addition to direct selling in more than 20 countries in North America, Europe and Asia/Pacific, Miltenyi Biotec also provides support for our customers through an extensive distributor network covering dozens of additional countries.
Cookie Settings
We use cookies in order to provide the best possible website experience for you. This includes cookies that are technically required to ensure a proper functioning of the website, as well as cookies which are used solely for anonymous statistical purposes, for more comfortable website settings, or for displaying personalized content. You are free to choose the categories you would like to permit. Please note that depending on your settings, the full functionality of the website may no longer be available. Further information can be found in our Privacy Statement.
Toll-like receptors (TLR) 7, 8, and 9 are involved in the early innate immune response as they help to recognize bacterial and viral pathogens. While TLR7/8 bind to single-stranded (ss) RNA, TLR9 is activated via unmethylated CpG-containing motifs of bacterial and viral DNA. The receptors are located in the endosomal compartment and signal via recruitment of MYD88 (myeloid differentiation primary response 88). The signaling cascade results in the activation of transcription factors NF-κB, AP-1, and/or IRF-7, which induces the expression of pro-inflammatory cytokines and type I IFNs.
While binding of agonists activates receptors, antagonist block the receptors and inhibit the interaction of agonist and receptor, which causes a weakened biological response to agonists. Our TLR7/8/9 antagonist ODN 2088 is a short single-stranded oligodeoxynucleotide (ODN) that can inhibit CpG ODN–mediated activation of TLR9 and activation of TLR7/8. In addition to our TLR antagonist, we offer controls with distinct inhibitory capacities.
We offer the TLR antagonist ODN 2088 and different sequence controls.
Table 1: Overview of available TLR7/8/9 antagonists and respective controls.
*Phosphorothioate backbone
Product | Sequence | Inhibits | ||
---|---|---|---|---|
TLR7 | TLR8 | TLR9 | ||
ODN 2088 | dT*dC*dC*dT*dG*dG*dC*dG*dG*dG*dG*dA*dA*dG*dT | Yes | Yes | Yes |
ODN 2088 Control (ODN 2087) | dT*dC*dC*dT*dG*dA*dG*dC*dT*dT*dG*dA* dA*dG*dT | Yes | Yes | No |
ODN 2088 Control (ODN 20958) | dT*dC*dC*dT*dA*dA*dC*dA*dA*dA*dA*dA*dA*dA*dT | Yes | No | No |
ODN 2088 Control (ODN 20959) | dT*dA*dA*dT*dG*dG*dC*dG*dG*dG*dG*dA*dA*dG*dT | Yes | Yes | No |
Copyright © 2021 Miltenyi Biotec and/or its affiliates. All rights reserved.