PepTivator Influenza A (H1N1) MP2, human

PepTivator Influenza A (H1N1) MP2, human

Influenza A (H1N1) MP2 is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the human influenza A virus MP2 protein (UniProt ID: C3W5Z0).
in vitro
stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.

Background information

The influenza A virus subtype H1N1 was the most common cause of human influenza in 2009. Some strains of H1N1 are endemic in humans, in pigs, and in birds. Complications in the upper and lower respiratory tract after influenza infection are common. Primary viral pneumonia is a severe complication after influenza infection, and occurs most frequently in humans with high risk for virus infections, e.g., elderly- or immunocompromised patients.


PepTivator Influenza A (H1N1) MP2 - research grade has been specifically developed for efficient
in vitro
stimulation of influenza A MP2–specific T cells. Peptides of 15 amino acids in length and 11 amino acids overlap represent an optimized solution for stimulating both CD4
and CD8
T cells in various applications, including:
  • Detection and analysis of influenza A MP2–specific effector/memory T cells in PBMCs by MACS Cytokine Secretion Assays, intracellular cytokine staining, or other technologies.
  • Isolation of viable influenza A MP2–specific CD4+ T cells with the CD154 MicroBead Kit, or of CD4+ and CD8+ T cells using the CD137 MicroBead Kit or MACS Cytokine Secretion Assay – Cell Enrichment and Detection Kits. Subsequently, cells can be expanded for generation of T cell lines.
  • Generation of influenza A MP2–specific effector/memory T cells from naive T cell populations.
  • Pulsing of antigen-presenting cells.
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