Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
C5AR1, C5a-R, C5AR, C5R1

Specifications for CD88 (C5AR) Antibody, anti-mouse, REAfinity™


Clone REA1206 recognizes the mouse CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 is expressed on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on microglia and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.
Additional information: Clone REA1206 displays negligible binding to Fc receptors.

Alternative names

C5AR1, C5a-R, C5AR, C5R1

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD88 (C5AR)
Alternative names of antigenC5AR1, C5a-R, C5AR, C5R1
Molecular mass of antigen [kDa]39
Distribution of antigenhepatocytes, endothelial cells, epithelial cells, granulocytes, macrophages, monocytes, mast cells, astrocytes, neutrophils
Entrez Gene ID12273
RRIDAB_2811451, AB_2811452, AB_2811453, AB_2811454, AB_2811455, AB_2811456, AB_2811457, AB_2811458, AB_2811450

Resources for CD88 (C5AR) Antibody, anti-mouse, REAfinity™


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References for CD88 (C5AR) Antibody, anti-mouse, REAfinity™


  1. Gerard, C. et al. (1992) Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. J. Immunol. 149(8): 2600-2606
  2. Sadik, C. D. et al. (2012) Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. Proc. Natl. Acad. Sci. U.S.A. 109(46): E3177-E3185
  3. Bosmann, M. et al. (2013) The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. Eur. J. Immunol. 43(7): 1907-1913

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