Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
B-cell activation protein

Extended validation for CD83 Antibody, anti-human, REAfinity™


Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA714
Cells were incubated with an excess of purified unconjugated CD83 (REA714) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD83 Antibody, anti-human, REAfinity™


Clone REA714 recognizes the human CD83 antigen, a 45 kDa glycoprotein member of the immunoglobulin superfamily of receptors. In humans, CD83 is expressed on the surface of activated dendritic cells (DCs) and can therefore be used as a marker for the phenotypical characterization of DC maturation. CD83 plays a role in antigen presentation and lymphocyte activation.
Additional information: Clone REA714 displays negligible binding to Fc receptors.

Alternative names

B-cell activation protein

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
cynomolgus monkey (
Macaca fascicularis
rhesus monkey (
Macaca mulatta
chimpanzee (
Pan troglodytes
, baboon, horse
Alternative names of antigenB-cell activation protein
Molecular mass of antigen [kDa]21
Distribution of antigenlymphocytes
Entrez Gene ID9308
RRIDAB_2659319, AB_2659320, AB_2659321, AB_2659322, AB_2659323, AB_2659324, AB_2659325, AB_2659326, AB_2659327, AB_2659318

Resources for CD83 Antibody, anti-human, REAfinity™


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References for CD83 Antibody, anti-human, REAfinity™


  1. Zhou, L.-J. et al. (1992) A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of J. Immunol. 149: 735-742
  2. Sallusto, F. and Lanzavecchia, A. (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179: 1109-1118
  3. Zhou, L.-J. and Tedder, T. F. (1995) Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. J. Immunol. 154: 3821-3835
  4. Lechmann, M. et al. (2002) CD83 on dendritic cells: more than just a marker for maturation. Trends Immunol. 23: 273-275
  5. Cao, W. et al. (2005) CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells. Biochem. J. 385: 85-93

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