Clone:
REA661
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
B7, B7-1, BB1

Specifications for CD80 Antibody, anti-human, REAfinity™

Overview

Clone REA661 recognizes the human CD80 antigen, also known as B7-1. CD80 is a 262 amino acid long 60 kDa molecule and a member of the immunoglobulin superfamily. Together with CD86 (B7-2) it belongs to the B7 family of costimulatory molecules. CD80 is expressed on activated B cells, dendritic cells, and monocytes/ macrophages. The interaction of CD80 with its ligands CD28 and CD152 (CTLA-4) plays a critical role in induction and regulation of immune responses. Binding of CD80 to CD28, which is constitutively expressed on T cells, provides a costimulatory signal and induces T cell proliferation and cytokine production. In contrast, binding to CTLA-4 strongly inhibits proliferation and IL-2 secretion by T cells.
Additional information: Clone REA661 displays negligible binding to Fc receptors.

Alternative names

B7, B7-1, BB1

Detailed product information

Technical specifications

CloneREA661
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
rhesus monkey (
Macaca mulatta
)
AntigenCD80
Alternative names of antigenB7, B7-1, BB1
Molecular mass of antigen [kDa]29
Distribution of antigenT cells, B cells, dendritic cells, Langerhans cells, macrophages, monocytes
Entrez Gene ID941
RRIDAB_2751414, AB_2802032, AB_2802016, AB_2659256, AB_2659257, AB_2751432

Reviews for CD80 Antibody, anti-human, REAfinity™

Staining CD80 in THP1 Cells

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CD80-Biotin, human (130-110-269)

The aim was to detect CD80 on PMA activated THP1 cells. This antibody did its work.

References for CD80 Antibody, anti-human, REAfinity™

Publications

  1. Freeman, G. J. et al. (1989) B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J. Immunol. 143(8): 2714-2722
  2. Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154(1): 97-105
  3. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
  4. Linsley, P. S. et al. (1993) The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11: 191-212

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