Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
T-cell differentiation antigen CD6

Specifications for CD6 Antibody, anti-mouse, REAfinity™


Clone REA311 recognizes the murine CD6 antigen, a Single-pass type I membrane protein which is expressed on most CD4+CD8+ double-positive, CD4+ or CD8+ single-positive thymocytes, and at highest levels on mature CD3+ thymocytes. In marked contrast to human CD6, mouse CD6 has a long cytoplasmic tail that is not closely related to other proteins. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. In thymocytes that express heterogeneous TCR, CD6 increases occur as double-positive thymocytes are selected to a single-positive stage. In contrast, in thymocytes from TCR transgenic mice, CD6 is barely increased following selection, suggesting that as functional avidity increases, requirements for CD6-dependent co-stimulation decrease. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection.
Additional information: Clone REA311 displays negligible binding to Fc receptors.

Alternative names

T-cell differentiation antigen CD6

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenT-cell differentiation antigen CD6
Molecular mass of antigen [kDa]71
Distribution of antigenT cells, thymocytes
Entrez Gene ID12511
RRIDAB_2658796, AB_2658797, AB_2658798, AB_2658799, AB_2658800, AB_2658801, AB_2658802, AB_2658803, AB_2658804, AB_2658805, AB_2876984

Resources for CD6 Antibody, anti-mouse, REAfinity™


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References for CD6 Antibody, anti-mouse, REAfinity™


  1. Robinson, W. H. et al. (1995) Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. J. Immunol. 155(10): 4739-4748
  2. Singer, N. G. et al. (2002) CD6: expression during development, apoptosis and selection of human and mouse thymocytes. Int. Immunol. 14(6): 585-597
  3. Whitney, G. et al. (1995) Cloning and characterization of murine CD6. Mol. Immunol. 32(1): 89-92

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