TLR7 and TLR8 are members of the Toll-like-receptor (TLR) family, recognizing (virally derived) double- or single-stranded RNA, leading to activation of immune cells.
ORN R-2176-dT activates both human TLR7 and TLR8 as well as murine TLR7 and induces a broad spectrum of cytokines from human PBMCs (IFN-α, IFN-γ, IL12, and TNF-α).
ORN R-2176-dT and ORN R-2176-dT Control can be used without a transfection reagent (e.g. DOTAP-Cl).

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