Recombinant mouse M-CSF regulates the differentiation, proliferation, and survival of osteoclasts, macrophages, monocytes, and their hematopoietic progenitors. As a potent hematopoietic cytokine, macrophage colony-stimulating factor (M-CSF) is involved in diverse processes, such as regulation of atherosclerosis or brain, bone resorption, placental development, and inflammatory responses. This recombinant protein has been optimized for use in cell culture, differentiation studies, and functional assays.