CD8b antibodies, human

CD8b antibodies, human

Clone: REA715 | Dilution: 1:50
Clone REA715 recognizes the human CD8b antigen, a single-pass type I membrane protein and member of the immunoglobulin superfamily, also known as T cell surface glycoprotein Lyt-3. The CD8 glycoprotein is expressed by thymocytes, mature T cells, and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex class I antigens and in signal transduction during the course of T cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. Most of peripheral blood CD8
+
T lymphocytes express the CD8a/CD8b heterodimer, while CD8
+
CD16
+
natural killer cells and CD8
+
T cell receptor γ/δ
+
T lymphocytes express only the CD8a/CD8a homodimer. CD8b can therefore be used to selectively bind to CD8
+
T cells while excluding CD8
+
NK cells.
Additional information: Clone REA715 displays negligible binding to Fc receptors.

Alternative names

CD8 beta chain, CD8 b chain, CD8b

Technical specifications

  • Antigen: CD8b
  • Clone: REA715
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD8 beta chain, CD8 b chain, CD8b
  • Entrez Gene ID: 926
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Norment, A. M. et al. (1988) A second subunit of CD8 is expressed in human T cells. EMBO J. 7(11): 3433-3439
    2. Baume, D. M. et al. (1990) Differential expression of CD8 alpha and CD8 beta associated with MHC-restricted and non-MHC-restricted cytolytic effector cells. Cell. Immunol. 131(2): 352-365
    3. Terry, L. A. et al. (1990) Differential expression and regulation of the human CD8 alpha and CD8 beta chains. Tissue Antigens 35(2): 82-91
Product options: 18
130-110-567

CD8b-FITC, human

for 30
tests
(1)
CAD 105.00
130-110-509

CD8b-FITC, human

for 100
tests
(1)
CAD 315.00
130-110-568

CD8b-PE, human

for 30
tests
(1)
CAD 130.00
130-110-510

CD8b-PE, human

for 100
tests
(1)
CAD 370.00
130-110-569

CD8b-APC, human

for 30
tests
(1)
CAD 170.00
130-110-511

CD8b-APC, human

for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 170.00
for 100
tests
(1)
CAD 410.00
for 30
tests
(1)
CAD 205.00
for 100
tests
(1)
CAD 455.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00
for 30
tests
(1)
CAD 180.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 180.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 105.00
for 100
tests
(1)
CAD 315.00

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