CD85h (ILT1) antibodies, human

CD85h (ILT1) antibodies, human

Clone: REA219 | Dilution: 1:11
Clone REA219 recognizes CD85h (ILT1), a member of the immunoglobulin-like transcripts (ILT) family of proteins. ILT family members compose of both activating and inhibitory receptors, where CD85h serves as an activating receptor. In contrast to inhibitory members, CD85h posesses a positively charged amino acid in its trasmembrane domain and a short cytoplasmic domain which is devoid of sequence motifs involved in signal transduction. To transduce activating signal, ILT1 forms a multiprotein complex with FCεRIγ. Expression of ILT1 is found on the surface of monocytes/macrophages, dendritic cells, and on a small subset of NK cells.
Additional information: Clone REA219 displays negligible binding to Fc receptors.

Alternative names

LILRA2, ILT1, LIR-7

Technical specifications

  • Antigen: CD85h (ILT1)
  • Clone: REA219
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRA2, ILT1, LIR-7
  • Distribution of antigen: macrophages, monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Nakajima, H. et al. (1999) Cutting edge: human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain. J. Immunol. 162: 5-8
    2. Chen, Y. et al. (2009) Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J. Mol. Biol. 386(3): 841-853
Product options: 12
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CAD 430.00
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CAD 120.00
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CAD 315.00

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