CD66c antibodies, human

CD66c antibodies, human

Clone: REA414 | Dilution: 1:11
Clone REA414 recognizes the human CD66c antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). Within the hematopoietic system, CD66c expression is limited to granulocytes and its precursors, where it serves homotypic and heterotypic adhesion, Ca
2+
mediated signaling, and is markedly upregulated from intracellular stores after activation. It is also found in epithelia of various organs. CD66c overexpression is found in a wide variety of epithelial cancer types such as lung, breast, colorectal, and hepatocellular carcinomas.
Additional information: Clone REA414 displays negligible binding to Fc receptors.

Alternative names

CEACAM6, CEAL, NCA, NCA-90

Technical specifications

  • Antigen: CD66c
  • Clone: REA414
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CEACAM6, CEAL, NCA, NCA-90
  • Entrez Gene ID: 4680
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: cancer stem cells, granulocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Neumaier, M. et al. (1988) Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. J. Biol. Chem. 263(7): 3202-3207
    2. Kiyokawa, N. et al. (2014) Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leuk. Res. 38(1): 42-48
    3. Guillaume, N. et al. (2011) CD66c expression in B-cell acute lymphoblastic leukemia: strength and weakness. Int J Lab Hematol 33(1): 92-96
Product options: 14
130-106-378

CD66c-PE, human

for 30
tests
(1)
CAD 130.00
130-106-305

CD66c-PE, human

for 100
tests
(1)
CAD 370.00
130-106-379

CD66c-APC, human

for 30
tests
(1)
CAD 170.00
130-106-306

CD66c-APC, human

for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 170.00
for 100
tests
(1)
CAD 410.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00
for 30
tests
(1)
CAD 180.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 180.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 120.00
for 100
tests
(1)
CAD 315.00