CD43 antibodies, human

CD43 antibodies, human

Clone: REA833 | Dilution: 1:50
Clone REA833 recognizes the human CD43 antigen, also known as leukosialin, a cell surface sialoglycoprotein that is involved in cell adhesion, differentiation, and activation. The CD43 antigen is expressed on most leukocytes, i.e., T cells, NK cells, granulocytes, monocytes, and macrophages, on hematopoietic stem cells and on platelets, but not on erythrocytes. Among B cells, CD43 is expressed on activated B cells and plasma cells but not on resting B cells, e.g., naive B cells. In bone marrow, CD43 is found on pro–B cells but is down-regulated during transition to the pre–B cell stage. CD43 is expressed on different myeloid and lymphoid tumors, including some B cell malignancies.
Additional information: Clone REA833 displays negligible binding to Fc receptors.

Alternative names

Spn, Leukosialin, GALGP, gpL115, Lsn, Sialophorin

Technical specifications

  • Antigen: CD43
  • Clone: REA833
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Spn, Leukosialin, GALGP, gpL115, Lsn, Sialophorin
  • Entrez Gene ID: 6693
  • Molecular mass of antigen [kDa]: 38
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, basophils, bone marrow, granulocytes, lymphocytes, macrophages, megakaryocytes, mesenchymal stem cells, monocytes, neutrophils, NK cells, plasma cells, platelets, red blood cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Whitehead, A. S. et al. (1989) Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. U.S.A. 86(8): 2819-2823
    2. Shelley, C. S. et al. (1990) Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. Biochem. J. 270(3): 569-576
    3. Kudo, S. et al. (1991) A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. J. Biol. Chem. 266(13): 8483-8489
Product options: 19
130-114-749

CD43-FITC, human

for 30
tests
(1)
CAD 110.00
130-114-592

CD43-FITC, human

for 100
tests
(1)
CAD 330.00
130-114-750

CD43-PE, human

for 30
tests
(1)
CAD 140.00
130-114-593

CD43-PE, human

for 100
tests
(1)
CAD 380.00
130-114-751

CD43-APC, human

for 30
tests
(1)
CAD 170.00
130-114-594

CD43-APC, human

for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 175.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 215.00
for 100
tests
(1)
CAD 470.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00
for 100
tests
(1)
CAD 435.00
for 30
tests
(1)
CAD 190.00
for 100
tests
(1)
CAD 440.00
for 30
tests
(1)
CAD 190.00
for 100
tests
(1)
CAD 440.00
for 30
tests
(1)
CAD 110.00
for 100
tests
(1)
CAD 330.00

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