CD38 antibodies, mouse

CD38 antibodies, mouse

Clone: REA616 | Dilution: 1:50
Clone REA616 recognizes the mouse CD38 antigen, a 42 kDa single-pass type II membrane protein, which is also known as ADP-ribosyl cyclase 1. CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. In the mouse, CD38
+
hematopoietic cells include B cells, subsets of T cells, monocytes, and macrophages. CD38 expression on these cells is modulated following activation and differentiation. In contrast to humans, CD38 expression is downregulated on mouse germinal center B cells and mouse mature plasma cells.
Additional information: Clone REA616 displays negligible binding to Fc receptors.

Alternative names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ADPRC 1, I-19, NIM-R5, T10

Technical specifications

  • Antigen: CD38
  • Clone: REA616
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ADPRC 1, I-19, NIM-R5, T10
  • Entrez Gene ID: 12494
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: B cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Oliver, A. M. et al. (1997) Mouse CD38 is down-regulated on germinal center B cells and mature plasma cells. J. Immunol. 158(3): 1108-1115
    2. Cockayne, D. A. et al. (1998) Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood 92(4): 1324-1333
    3. Howard, M. et al. (1993) Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262(5136): 1056-1059
    4. Bean, A. G. et al. (1995)
      CD38 expression on mouse T cells: CD38 defines functionally distinct subsets of alpha beta TCR
      +
      CD4
      -
      CD8
      -
      thymocytes.
      Int. Immunol. 7(2): 213-221
Product options: 3
130-122-955

CD38-FITC, mouse

30 µg in 200 µL (1)
CAD 60.00
130-123-571

CD38-PE, mouse

30 µg in 200 µL (1)
CAD 75.00
130-122-946

CD38-APC, mouse

30 µg in 200 µL (1)
CAD 110.00

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