CD370 (CLEC9A) antibodies, mouse

CD370 (CLEC9A) antibodies, mouse

Clone: 7H11 | Dilution: 1:50
Clone 7H11 recognizes CD370 C-type lectin 9A (CLEC9A), also known as DC NK lectin group receptor-1 (DNGR-1). It is a protein of 264 amino acids expressed at high level on CD8a
+
dendritic cells and at lower level on mPDCA-1
+
plasmacytoid dendritic cells. CD370 (CLEC9A) recognizes necrotic cell associated epitopes and plays an important role in crosspresentation of dead cell derived antigens.

Alternative names

DNGR-1

Technical specifications

  • Antigen: CD370 (CLEC9A)
  • Clone: 7H11
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: DNGR-1
  • Entrez Gene ID: 232414
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
    2. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
    3. Joffre, O. P. et al. (2010)
      Efficient and versatile manipulation of the peripheral CD4
      +
      T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
      Eur. J. Immunol. 40(5): 1255-1265
Product options: 1
30 µg in 200 µL (1)
CAD 235.00

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