CD329 (Siglec-9) antibodies, human

CD329 (Siglec-9) antibodies, human

Clone: REA492 | Dilution: 1:11
Clone REA492 recognizes the human CD329 antigen, a single-pass type I membrane protein also known as sialic acid-binding Ig-like lectin 9 (Siglec-9). Siglecs are characterized by an amino-terminal V-set immunoglobulin domain that binds to sialic acid residues, followed by a variable number of C2-set immunoglobulin-like domains. CD329 is expressed quite broadly among human blood leukocytes, being found on monocytes, neutrophils, B cells, NK cells, and minor subsets of T cells. Ligation of CD329 induced apoptosis in adult neutrophils in a caspase-dependent manner; in contrast, its activation under inflammatory conditions resulted in a caspase-independent autophagic type of cell death. These disparate actions implicate a unique role for CD329 in modulating cell survival under inflammatory and basal conditions.
Additional information: Clone REA492 displays negligible binding to Fc receptors.

Alternative names

CDw329, FOAP-9, OBBP-LIKE, Siglec-9

Technical specifications

  • Antigen: CD329 (Siglec-9)
  • Clone: REA492
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDw329, FOAP-9, OBBP-LIKE, Siglec-9
  • Entrez Gene ID: 27180
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: B cells, granulocytes, leukocytes, macrophages, monocytes, T cells, lymphocytes, neutrophils, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, PE-Vio770, Biotin
  • Selected references

    1. Foussias, G. et al. (2000) Identification and molecular characterization of a novel member of the siglec family (SIGLEC9). Genomics 67(2): 171-178
    2. Zhang, J. Q. et al. (2000) Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes. J. Biol. Chem. 275(29): 22121-22126
    3. Tanida, S. et al. (2013) Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth. J. Biol. Chem. 288(44): 31842-31852
Product options: 8
for 30
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CAD 190.00
for 100
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CAD 450.00
for 30
tests
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CAD 130.00
for 100
tests
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CAD 360.00
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CAD 165.00
for 100
tests
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CAD 395.00
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tests
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CAD 105.00
for 100
tests
(1)
CAD 310.00

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