CD321 (JAM1) antibodies, human

CD321 (JAM1) antibodies, human

Clone: REA605 | Dilution: 1:11
Clone REA605 recognizes the human CD321 antigen, a cell-surface adhesion molecule, also known as JAM1 or JAMA. CD321 is a type I transmembrane glycoprotein belonging to the immunoglobin superfamily. It has two extracellular Ig-like domains, a transmembrane region and a short cytosolic tail.
CD321 is expressed on a variety of cell types: erythrocytes, leukocytes, platelets, as well as endothelial and epithelial cells. CD321 has different functions. It is a regulator of tight junction assembly in epithelia and acts as a receptor for reovirus. Furthermore CD321 binds integrin LFA1 and is involved in leukocyte transmigration. In addition, CD321 is a platelet receptor.
Additional information: Clone REA605 displays negligible binding to Fc receptors.

Alternative names

JAM-1, JAM-A, PAM-1, F11 R

Technical specifications

  • Antigen: CD321 (JAM1)
  • Clone: REA605
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: JAM-1, JAM-A, PAM-1, F11 R
  • Entrez Gene ID: 50848
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: red blood cells, leukocytes, platelets, endothelial cells, epithelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Ozaki, H. et al. (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J. Immunol. 163(2): 553-557
    2. Sobocka, M. B. et al. (2000) Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95(8): 2600-2609
    3. Fraemohs, L. et al. (2004) The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain. J. Immunol. 173(10): 6259-6264
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CAD 430.00
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CAD 180.00
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CAD 430.00
for 30
tests
(1)
CAD 130.00
for 100
tests
(1)
CAD 315.00

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