CD318 (CDCP1) antibodies, human

CD318 (CDCP1) antibodies, human

Clone: REA194 | Dilution: 1:11
Clone REA194 recognizes CD318, a type I transmembrane protein which is also known as CUB domain-containing protein 1 (CDCP1) or SIMA135. CD318 has an approximate molecular weight of 93 kDa and contains an extracellular domain with three regions with low homology to complement protein subcomponents C1r/C1s, urchin embryonic growth factor, and bone morphogenetic protein 1 (CUB) domains. CD318 has been suggested to be an interacting partner of Src family kinase and protein kinase Cδ. It has been shown that CD318 plays a role in cancer progression and the development of metastases. CD318 expression is found widely in normal tissues, whereas an aberrant overexpression is suggested to be associated with tumor cells.
Additional information: Clone REA194 displays negligible binding to Fc receptors.

Alternative names

CDCP1, SIMA135, TRASK

Technical specifications

  • Antigen: CD318 (CDCP1)
  • Clone: REA194
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CDCP1, SIMA135, TRASK
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Liu, H. et al. (2011) CUB-domain–containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc. Natl. Acad. Sci. U.S.A. 108: 1379-1384
    2. Conze, T. et al. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann. N. Y. Acad. Sci. 996: 222-226
    3. Scherl-Mostageer, M. et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20(32): 4402-4408
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