CD177 antibodies, human

CD177 antibodies, human

Clone: REA258 | Dilution: 1:11
Clone REA258 recognizes CD177, which is also known as neutrophil specific antigen 1. CD177, a member of the µPAR family, is a 58–64 kDa glycosylphosphatidylinositol-anchored glycoprotein expressed exclusively by subset of neutrophils, neutrophilic metamyelocytes, and myelocytes and is suggested to play a role in neutrophil mediated immune reponse as evident by its up-regulation on neutrophils in a number of inflammatory settings such as bacterial infection. Furthermore, CD177 can directly bind to PECAM-1 allowing neutrophil-endothelial cell interactions and thus contributing to neutrophil transmigration. Overexpression of CD177 is also seen in patients with polycythemia vera, making it a useful diagnostic marker.
Additional information: Clone REA258 displays negligible binding to Fc receptors.

Alternative names

HNA-2a, NB1, NB1 GP, PRV-1, PRV1

Technical specifications

  • Antigen: CD177
  • Clone: REA258
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HNA-2a, NB1, NB1 GP, PRV-1, PRV1
  • Entrez Gene ID: 57126
  • Molecular mass of antigen [kDa]: 41
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Sachs, U. J. H. et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J. Biol. Chem. 282: 23603-23612
    2. Monti, M. et al. (2017) Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells. PLoS One 12
    3. Beyrau, M. et al. (2012) Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity. Open Bio 2: 120134
    4. Wu, Z. et al. (2016) Heterogeneity of human neutrophil CD177 expression results from CD177P1 pseudogene conversion. PLoS Genet. 12(5)
    5. Tackeray, J. T. et al. (2016) Targeting amino acid metabolism for molecular imaging of inflammation early after myocardial infarction. Theranostics 6(11): 1768-1779
Product options: 12
for 30
tests
(1)
CAD 110.00
for 100
tests
(1)
CAD 315.00
130-101-525

CD177-PE, human

for 30
tests
(1)
CAD 130.00
130-101-523

CD177-PE, human

for 100
tests
(1)
CAD 370.00
130-101-512

CD177-APC, human

for 30
tests
(1)
CAD 170.00
130-101-511

CD177-APC, human

for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00
for 30
tests
(1)
CAD 190.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 120.00
for 100
tests
(1)
CAD 315.00

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