CD172a (SIRPα) antibodies, human

CD172a (SIRPα) antibodies, human

Clone: REA144 | Dilution: 1:50
Clone REA144 recognizes CD172a, which is also known as signal regulatory protein α (SIRPα). CD172a belongs to the Ig superfamily and is 75–110 kDa single-pass type I regulatory membrane protein. Expression of CD172a is found primarily on hematopoietic stem cells, neurons, and myeloid cells such as macrophages, monocytes, dendritic cells, granulocytes, and myeloid progenitors. CD172a phosphorylated at intracellular tyrosine sites, in response to extracellular stimuli, serves as the docking site for phosphatases such as SHP-1, SHP-2, or SHIP, which inturn desphosphorylate molecules involved in regulating various physiological effects. CD47 has been suggested as a ligand of CD172a.
Additional information: Clone REA144 displays negligible binding to Fc receptors.

Alternative names

SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp

Technical specifications

  • Antigen: CD172a (SIRPα)
  • Clone: REA144
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp
  • Entrez Gene ID: 140885
  • Molecular mass of antigen [kDa]: 52
  • Distribution of antigen: macrophages, dendritic cells, myeloid cells, monocytes, hematopoietic stem cells, neurons, granulocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, APC-Vio770
  • Selected references

    1. Motegi, S. et al. (2003) Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J. 22(11): 2634-2644
    2. Jung, C. J. et al. (2016) Comparative analysis of piggyBac, CRISPR/Cas9 and TALEN mediated BAC transgenesis in the zygote for the generation of humanized SIRPA rats. Sci. Rep. 6: 31455
    3. Oshima, K. et al. (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519(1-3): 1-7
Product options: 4
for 30
tests
CAD 195.00
for 100
tests
CAD 430.00
for 30
tests
CAD 180.00
for 100
tests
CAD 435.00