CD106 (VCAM-1) antibodies, mouse

CD106 (VCAM-1) antibodies, mouse

Clone: REA971 | Dilution: 1:50
Clone REA971 recognizes the mouse CD106 antigen, a 110 kDa single-chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow cells, stromal cells, and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
Additional information: Clone REA971 displays negligible binding to Fc receptors.

Alternative names

VCAM1, INCAM-100

Technical specifications

  • Antigen: CD106 (VCAM-1)
  • Clone: REA971
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: VCAM1, INCAM-100
  • Entrez Gene ID: 22329
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J. Immunol. 153(9): 4088-4098
    2. Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82(6): 2952-2965
    3. Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression Cell Stem Cell 11(2): 220-230
Product options: 10
30 µg in 200 µL (1)
CAD 60.00
150 µg in 1 mL (1)
CAD 220.00
30 µg in 200 µL (1)
CAD 75.00
150 µg in 1 mL (1)
CAD 260.00
30 µg in 200 µL (1)
CAD 110.00
150 µg in 1 mL (1)
CAD 430.00
30 µg in 200 µL (1)
CAD 185.00
150 µg in 1 mL (1)
CAD 535.00
30 µg in 200 µL (1)
CAD 75.00
150 µg in 1 mL (1)
CAD 240.00

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