Anti-Syk antibodies, human

Anti-Syk antibodies, human

Clone: REA111 | Dilution: 1:11
Clone REA111 recognizes Syk, a 72 kDa non-receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM, is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk.
Additional information: Clone REA111 displays negligible binding to Fc receptors.

Alternative names

p72-Syk

Technical specifications

  • Antigen: Syk
  • Clone: REA111
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: p72-Syk
  • Entrez Gene ID: 6850
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: B cells, T cells, myeloid cells, breast
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770
  • Selected references

    1. Kurosaki, T. et al. (1995) Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182(6): 1815-1823
    2. Sada, K. et al. (2001) Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130: 177-186
    3. Siraganian, R. P. et al. Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38(16-18): 1229-1233
Product options: 8
for 30
tests
(1)
CAD 105.00
for 100
tests
(1)
CAD 315.00
for 30
tests
(1)
CAD 130.00
for 100
tests
(1)
CAD 370.00
for 30
tests
(1)
CAD 170.00
for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00

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