Anti-NKp80 antibodies, human

Anti-NKp80 antibodies, human

Clone: REA845 | Dilution: 1:50
Clone REA845 recognizes the human NKp80 antigen, an 80 kDa homodimeric surface molecule belonging to the family of C-type lectin-like receptors. NKp80 is expressed on all human natural killer (NK) cells and on a small subset of effector memory CD8
+
T cells. NKp80 stimulates NK cell cytotoxicity and cytokine release and appears to co-operate with other triggering receptors to induce optimal NK cell activation upon interaction with potential target cells. The ligand of NKp80 is activation-induced C-type lectin (AICL), also called CLEC2B.
Additional information: Clone REA845 displays negligible binding to Fc receptors.

Alternative names

KLRF1, CLEC5C

Technical specifications

  • Antigen: NKp80
  • Clone: REA845
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KLRF1, CLEC5C
  • Entrez Gene ID: 51348
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Kuttruff, S. et al. (2009) NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood 113: 358-369
    2. Welte, S. et al. (2006) Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat. Immunol. 7: 1334-1342
    3. Vitale, M. et al. (2001) Identification of NKp80, a novel triggering molecule expressed by human NK cells. Eur. J. Immunol. 31: 233-242
Product options: 17
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CAD 330.00

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