Anti-Ly-49A antibodies, mouse

Anti-Ly-49A antibodies, mouse

Clone: REA1018 | Dilution: 1:50
Clone REA1018 recognizes th mouse Ly-49A antigen, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk, and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.
Additional information: Clone REA1018 displays negligible binding to Fc receptors.

Alternative names

Klra1, CH29-493D4.3, Klra22, Ly49v

Technical specifications

  • Antigen: Ly-49A
  • Clone: REA1018
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Klra1, CH29-493D4.3, Klra22, Ly49v
  • Entrez Gene ID: 16627
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Daws, M. R. et al. (1999) H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97(4): 656-664
    2. Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J. Immunol. 165: 6922-6932
    3. Zimmer, J. et al. (2001)
      H-2D ligand expression by Ly49A
      +
      natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function.
      J. Exp. Med. 194(10): 1531-1539
Product options: 12
30 µg in 200 µL (1)
CAD 60.00
150 µg in 1 mL (1)
CAD 220.00
30 µg in 200 µL (1)
CAD 75.00
150 µg in 1 mL (1)
CAD 260.00
30 µg in 200 µL (1)
CAD 110.00
150 µg in 1 mL (1)
CAD 430.00
30 µg in 200 µL (1)
CAD 155.00
30 µg in 200 µL (1)
CAD 185.00
30 µg in 200 µL (1)
CAD 190.00
30 µg in 200 µL (1)
CAD 185.00
30 µg in 200 µL (1)
CAD 240.00
30 µg in 200 µL (1)
CAD 70.00

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