Anti-IRF-8 antibodies, human and mouse

Anti-IRF-8 antibodies, human and mouse

Clone: REA516 | Dilution: 1:11
Clone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence–binding protein (ICSBP). IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. IRF-8 is expressed at very high levels in mononuclear phagocytes, and regulates granulocyte/macrophage differentiation and dendritic cell (DC) development. Acting in heterodimeric complexes with other transcription factors, IRF-8 also controls the transcriptional response of mature myeloid cells to interferons and Toll-like receptor agonists, a response in which IRF-8 binds and transactivates the promotors of IL12B and NOS2. IRF-8 knockout mice display a loss of CD8a
+
lymphoid DCs, CD103
+
tissue myeloid DCs, and plasmacytoid DCs.
Additional information: Clone REA516 displays negligible binding to Fc receptors.

Alternative names

IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B

Technical specifications

  • Antigen: IRF-8
  • Clone: REA516
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IRF8, H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B
  • Entrez Gene ID: 3394, 15900
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: dendritic cells, granulocytes, monocytes, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Driggers, P. H. et al. (1990) An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U.S.A. 87(10): 3743-3747
    2. Hambleton, S. et al. (2011) IRF8 mutations and human dendritic-cell immunodeficiency. N. Engl. J. Med. 365(2): 127-138
    3. Yoshida, Y. et al. (2014) The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity 40(2): 187-198
Product options: 4
for 30
tests
(1)
CAD 130.00
for 100
tests
(1)
CAD 370.00
for 30
tests
(1)
CAD 170.00
for 100
tests
(1)
CAD 390.00

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