Anti-IgE antibodies, human

Anti-IgE antibodies, human

Clone: REA1049 | Dilution: 1:50
Clone REA1049 recognizes the IgE isotype of human immunoglobulins. IgE is the shortest-lived immunoglobulin with a half-life of two days in serum. IgE plays an important role in allergy. It is especially associated with type 1 hypersensitivity, where IgE shows high-affinity binding to Fc receptors expressed on the surface of mast cells. Antigen binding to Fc receptor–bound IgE upon re-exposure to specific allergens results in degranulation and the release of a variety of mediators, such as histamine and cytokines.
IgE has two main receptors: the high-affinity receptor FcεRI, which is expressed only on mast cells and basophils, and the low-affinity receptor FcεRII (CD23), which is expressed on B cells.
Additional information: Clone REA1049 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: IgE
  • Clone: REA1049
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 3497
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, basophils, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
Product options: 20
for 30
tests
(1)
CAD 110.00
for 100
tests
(1)
CAD 330.00
for 30
tests
(1)
CAD 140.00
for 100
tests
(1)
CAD 380.00
for 30
tests
(1)
CAD 170.00
for 100
tests
(1)
CAD 390.00
for 30
tests
(1)
CAD 175.00
for 100
tests
(1)
CAD 430.00
for 30
tests
(1)
CAD 220.00
for 100
tests
(1)
CAD 470.00
for 30
tests
(1)
CAD 195.00
for 100
tests
(1)
CAD 415.00
for 30
tests
(1)
CAD 200.00
for 100
tests
(1)
CAD 435.00
for 30
tests
(1)
CAD 190.00
for 100
tests
(1)
CAD 440.00
for 30
tests
(1)
CAD 225.00
for 100
tests
(1)
CAD 565.00
for 30
tests
(1)
CAD 110.00
for 100
tests
(1)
CAD 330.00

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