Anti-HLA-A2 antibodies, human

Anti-HLA-A2 antibodies, human

Clone: REA517 | Dilution: 1:50
Clone REA517 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells.
Additional information: Clone REA517 displays negligible binding to Fc receptors.

Alternative names

MHC class I HLA-A2

Technical specifications

  • Antigen: HLA-A2
  • Clone: REA517
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MHC class I HLA-A2
  • Entrez Gene ID: 3105
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: nucleated cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, PE-Vio770, APC, Biotin
  • Selected references

    1. Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329(6139): 506-512
    2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
    3. Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425(22): 4496-4507
Product options: 10
for 30
tests
(1)
CAD 110.00
for 100
tests
(1)
CAD 330.00
for 30
tests
(1)
CAD 140.00
for 100
tests
(1)
CAD 380.00
for 30
tests
(1)
CAD 190.00
for 100
tests
(1)
CAD 435.00
for 30
tests
(1)
CAD 160.00
for 100
tests
(1)
CAD 370.00
for 30
tests
(1)
CAD 115.00
for 100
tests
(1)
CAD 330.00

Related products

3 products available