Anti-GLAST (ACSA-1) antibodies, human, mouse, rat

Anti-GLAST (ACSA-1) antibodies, human, mouse, rat

Clone: ACSA-1 | Dilution: 1:11
The antibody ACSA-1 (astrocyte cell surface antigen-1) is specific for an extracellular epitope of the astrocyte specific transmembrane glycoprotein GLAST in the central nervous system (CNS). Besides GLT-1, GLAST is the most abundant glutamate transporter and is predominantly expressed by astrocytes in the developing and neonatal mammalian CNS. Also radial glia, which belong to the astrocyte lineage and play important roles in development, are known to express GLAST. Postnatally, radial glia only persist in a few regions, such as Bermann glia in the cerebellum, Müller glia in the retina, and radial glia in the dentate gyrus of the adult hippocampus.

Alternative names

SLC1A3, EA6, EAAT1, GLAST1

Technical specifications

  • Antigen: GLAST (ACSA-1)
  • Clone: ACSA-1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: SLC1A3, EA6, EAAT1, GLAST1
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, pure
  • Selected references

    1. Storck, T. et al. (1992)
      Structure, expression, and functional analysis of a Na
      +
      -dependent glutamate/aspartate transporter from rat brain.
      Proc. Natl. Acad. Sci. U.S.A. 8(22): 10955-10959
    2. Wahle, S. and Stoffel, W. (1996) Membrane topology of the high-affinity L-glutamate transporter (GLAST- 1) of the central nervous system. J. Cell Biol. 135(6): 1867-1877
    3. Kimelberg, H.K. (2004) The problem of astrocyte identity. Neurochem. Int. 45(2-3): 191-202
    4. Kriegstein, A. R. and Götz, M. (2003) Radial glia diversity: a matter of cell fate. Glia 43: 37-43
    5. Jackson, W. S. et al. (2014) Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brain. PLoS One 9(4): e95958
    6. Morris, L. G. et al. (2013) Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat. Genet. 45(3): 253-261
    7. Mich, J. K. et al. (2014) Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife 3: e02669
  • Special protocols

Product options: 3
for 30
tests
(1)
CAD 175.00
for 100
tests
(1)
CAD 390.00
100 µg in 1 mL
CAD 470.00