Clone:
REAL1159
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, IDP, Cytosolic NADP-isocitrate dehydrogenase, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD

Specifications for IDH1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1159 is an antibody fragment derived from the full IDH1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1159 recognizes the IDH1 enzyme, also known as Isocitrate dehydrogenase (NADP) cytoplasmic, that plays an important role in lipid biosynthesis in different tissues such as the liver, adipose tissues, brain and tumors. Mutations of IDH is related to the progress and prognosis of certain tumors and have been found in numerous cancers, mainly in gliomas, chondrosarcomas or enchondromas, and cholangiocarcinomas. IDH1 is considered to be a specific biomarker for early diagnosis, prognosis and targeted therapy for tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, IDP, Cytosolic NADP-isocitrate dehydrogenase, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD

Detailed product information

Technical specifications

CloneREAL1159
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Cross-reactivitynon-human primate
AntigenIDH1
Alternative names of antigenIsocitrate dehydrogenase [NADP] cytoplasmic, IDH, IDP, Cytosolic NADP-isocitrate dehydrogenase, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD

Resources for IDH1 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for IDH1 Antibody, anti-human, REAdye_lease™

Publications

  1. Dang, L. et al. (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 739(744): 462-7274
  2. Mondesir, J. et al. (2016) IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives. J Blood Med. 7: 171-180
  3. Mehrjardi, M. Z. et al. (2020) Current biomarker-associated procedures of cancer modeling-a reference in the context of IDH1 mutant glioma. Cell Death Dis 11(11): 998

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