Clone:
REAL1060
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CASQ2, Calsequestrin, cardiac muscle isoform

Specifications for Calsequestrin 2 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1060 is an antibody fragment derived from the full Calsequestrin 2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1060 recognizes Calsequestrin 2, also known as CASQ2. Calsequestrin 2 is a major Ca2
+
-storage/buffer protein present in the sarcoplasmic reticulum of cardiac (CASQ2) muscles. It plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. Calsequestrin 2 is identified as a breast cancer-related gene in tumor-microenvironment interactions during tumor growth and metastasis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CASQ2, Calsequestrin, cardiac muscle isoform

Detailed product information

Technical specifications

CloneREAL1060
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCalsequestrin 2
Alternative names of antigenCASQ2, Calsequestrin, cardiac muscle isoform
Distribution of antigencardiac cells

Resources for Calsequestrin 2 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Calsequestrin 2 Antibody, anti-human, REAdye_lease™

Publications

  1. Titus, E. W. et al. (2020) The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. Nat. Struct. Mol. Biol. 27(12): 1142-1151
  2. Kim, J. H. et al. (2022) Calsequestrin 2 overexpression in breast cancer increases tumorigenesis and metastasis by modulating the tumor microenvironment. Mol Oncol. 16(2): 466-484
  3. Al-Ansari, F. et al. (2018) Correlation between thyroidal and peripheral blood total T cells, CD8(+) T cells, and CD8(+) T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves' ophthalmopathy. 43(4): 264-274

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