Clone:
4E1.2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG3κ
Applications:
FC
Alternative names:
VSIG9, Vstm3, WUCAM

Specifications for TIGIT Antibody, anti-human

Overview

Clone 4E1.2 reacts with a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is called TIGIT (T cell immunoglobulin and ITIM domain). It is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation.

Alternative names

VSIG9, Vstm3, WUCAM

Detailed product information

Technical specifications

Clone4E1.2
Clonalitymonoclonal
Isotypemouse IgG3κ
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenTIGIT
Alternative names of antigenVSIG9, Vstm3, WUCAM
Molecular mass of antigen [kDa]24
Entrez Gene ID201633
RRIDAB_10830226

Resources for TIGIT Antibody, anti-human

Certificates

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References for TIGIT Antibody, anti-human

Publications

  1. Yu, X. et al. (2008) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol. 10: 48-57

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