Clone:
REA395
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TCRA, TCR Va3.2, TCR-Va3.2

Specifications for TCR Vα3.2 (b, c) Antibody, anti-mouse, REAfinity™

Overview

Clone REA395 recognizes the mouse Vα 3.2 T cell receptor (TCR Vα3.2) of mice having the b (e.g., C57BL/6) and c (e.g., SJL, NOD) haplotypes, but not with the strains having the a (Balb/c) or d (DBA/2) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules.
Additional information: Clone REA395 displays negligible binding to Fc receptors.

Alternative names

TCRA, TCR Va3.2, TCR-Va3.2

Detailed product information

Technical specifications

CloneREA395
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vα3.2 (b, c)
Alternative names of antigenTCRA, TCR Va3.2, TCR-Va3.2
Molecular mass of antigen [kDa]16
Distribution of antigenT cells
Entrez Gene ID21473
RRIDAB_2653703, AB_2653704, AB_2653705, AB_2653706, AB_2653707, AB_2653708, AB_2653709, AB_2653710, AB_2653711, AB_2653712, AB_2653713, AB_2653714, AB_2653715, AB_2653716, AB_2653717, AB_2653702

Resources for TCR Vα3.2 (b, c) Antibody, anti-mouse, REAfinity™

Certificates

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References for TCR Vα3.2 (b, c) Antibody, anti-mouse, REAfinity™

Publications

  1. Sim, B. C. et al. (1997) V alpha 3.2 selection in MHC class I mutant mice: evidence for an alternate orientation of TCR-MHC class I interaction. J. Immunol. 159(7): 3322-3329
  2. Pereira, P. et al. (1997) The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proc. Natl. Acad. Sci. U.S.A. 94(11): 5761-5766
  3. von Essen, M. R. et al. (2012) Mechanisms behind functional avidity maturation in T cells. Clin. Dev. Immunol. 2012: 163453

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