Clone:
REAL773
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
PLB, Cardiac phospholamban, PLN

Specifications for Phospholamban Antibody, anti-human, REAdye_lease™

Overview

Clone REAL773 is an antibody fragment derived from the full Phospholamban antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL773 recognizes Phospholamban (PLB), also known as Cardiac phospholamban, a micropeptide protein that in humans is encoded by the PLN gene. Phospholamban (PLB) modulates the contractility of the heart muscle and it plays an important role in calcium homeostasis. Phospolamban (PLB) is a key regulator of cardiac diastolic function. Mutations in the PLN gene are caused in human dilated Cardiomyopathy.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

PLB, Cardiac phospholamban, PLN

Detailed product information

Technical specifications

CloneREAL773
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenPhospholamban
Alternative names of antigenPLB, Cardiac phospholamban, PLN

Resources for Phospholamban Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Phospholamban Antibody, anti-human, REAdye_lease™

Publications

  1. Schmitt, J. P. et al. (2003) Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299(5611): 1410-1413
  2. Shaikh, S. A. et al. (2016) Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase? J. Mol. Cell. Cardiol. 91: 81-91
  3. Te Rijdt, W. P. et al. (2019) Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy Cardiovasc Pathol. 40: 2-6

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